This essay allows us to identify patterns and explain why things turned out the way that they did. How do I choose a topic and get started? Try choosing a major event, either in your own life or an event of historical significance. For example, The Great Depression.
Cause of The Great Depression: stock market crashHow would we elaborate? We'd discuss the behaviors, carelessness, errors, and even cultural attitudes that led to the crash—explaining why it was devastating. Effects of the Great Depression: joblessness & poverty What should we say about the effects?In a short essay, it might be difficult to tackle the cause and all of the many effects of a big event like the Great Depression.
Recent advances in fundamental science and in our understanding of the pathogenic processes underlying type 1 diabetes and its complications in animal models offer tremendous promise for the development of new therapies. Recently, a few immunoregulatory agents have shown promise for the delay of type 1 diabetes onset or progression in human studies. However, for such agents to reach their full therapeutic potential, a number of obstacles must be overcome. These include a better understanding of triggers of autoimmunity, immunoregulation and tolerance to self, mechanisms of immune-mediated destruction of pancreatic beta cells, and beta cell growth, function and regeneration. Better understanding in these areas is needed to develop therapies that will block beta cell autoimmune destruction, spare normal immune responses to pathogens, and allow beta cells to recover function in already affected patients. Research is needed for the development of improved models, in which to test new therapies and measures to predict or assess response to therapy in early trials of potential therapies. Also needed are improved methods to monitor disease progression, such as methods to assess beta cell mass and inflammation non-invasively.
The success of islet transplantation in freeing individuals with established and brittle type 1 diabetes from the need for insulin therapy has yielded great excitement. However, islet transplantation requires immunosuppression that is associated with significant side effects and long-term risks. Moreover, protocols generally require two donor pancreata per recipient; therefore, current levels of organ donation do not provide sufficient organs for all of the people who could potentially benefit from this therapy. Finally, the transplanted islets often are observed to decline in function with time, and many patients eventually need to resume some exogenous insulin therapy. The recent success in islet transplantation provides additional impetus for research to develop methods to attain an unlimited supply of islets or beta cells for transplantation; to improve the viability of transplanted islets; and to minimize the toxicity of immunomodulation required for transplant acceptance and maintenance.
Applicants may submit or have an R01 (or other equivalent) grant application pending concurrently with their Type 1 Diabetes Pathfinder Award application. However, if that pending R01 (or other equivalent) grant is awarded in the fiscal year of the competition (fiscal years end September 30) with a start date of September 30 or earlier in that fiscal year, then the applicant is no longer eligible to receive the Type 1 Diabetes Pathfinder Award. Please see section 3, below, for more information about limitations on overlapping applications.
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The Type 1 Diabetes Pathfinder Award (DP2) grant supports innovative research that has the potential to produce a major impact on a broad area of biomedical or behavioral research that is relevant to type 1 diabetes and its complications. A DP2 grant application does not have extensive background material, and the essay focuses on the goals of the Type 1 Diabetes Pathfinder Award program. Preliminary data are not required but may be included. Accordingly, reviewers will emphasize the following: 1) the importance of the scientific problem and the potential impact of the research, 2) the novelty and innovativeness of the approach, and 3) evidence of the applicant's potential for creative and innovative research as an early stage investigator.
Project Description: Describe the scientific problem that you propose to address, its importance, and how solving this problem would have a major impact on a broad area of biomedical/behavioral science. Why is the planned research uniquely suited to the Type 1 Diabetes Pathfinder Award program, rather than a traditional grant mechanism? How is this project distinct from other research that may be supported in your laboratory? The essay should provide a brief overview of the future direction of work after completion of the research in the initial grant
Research Strategy: Upload Essay here. Submit an essay that addresses (1) the significance and potential impact of the project and (2) what makes the approaches exceptionally innovative and how the applicant will address risks and challenges. The description of the scientific plan should be written with a level of detail appropriate for reviewers who are broadly knowledgeable but who may not be directly involved in the proposed area of research. To focus the essay on the goals of the Type 1 Diabetes Pathfinder Award program and the review criteria for applications, presentation of the proposed research as a series of specific aims is discouraged. Preliminary data are allowed but not required. The essay should include the following sections within the page limit, in the following order, with the headings shown:
Cover Letter: Provide names and affiliations of significant collaborators for the Type 1 Diabetes Pathfinder Award project. Biosketches of collaborators are not allowed. Provision of names here is only to help exclude conflicts during reviewer assignment. Information regarding any collaborators may be included in the Essay.
When multiple years are involved, awardees will be required to submit the annually and financial statements as required in the Progress reports for multi-year funded awards are due annually on or before the anniversary of the budget/project period start date of award. The reporting period for multi-year funded award progress report is the calendar year preceding the anniversary date of the award. Information on the content of the progress report and instructions on how to submit the report using the RPPR are posted at .